DRCMR

Cortical lessions and grey matter dysfunction in Multiple Sclerosis

Imaging plays a pivotal role in multiple sclerosis (MS) diagnosis and monitoring. It can help us uncover and understand the yet unknown mechanisms that contribute to the large variety of symptoms in MS.

For example, cortical pathology is now known to significantly contribute to disability in multiple sclerosis (MS) and has therefore attracted considerable interest in the last decade. However, we are yet to understand the impact of cortical damage on both the connectivity and functional integrity of the affected area and other parts of the central nervous system.

In this project, we exploit the greater sensitivity of 7 Tesla magnetic resonance imaging (MRI) to cortical lesions, together with quantitative imaging sequences and transcranial magnetic stimulation (TMS) to comprehensively map the role of cortical damage in different subtypes of MS.

Using both MRI and TMS, this project addresses two main research questions:

1. What is the impact of individual cortical lesions, specifically in the primary sensorimotor hand area, on hand dexterity in different subtypes of MS
2. What role do focal and diffuse cortical myelin changes play in relation to physical and cognitive function in primary progressive MS

Impact

This project will reveal key insights into how cortical demyelination and damage, both regionally and globally, contribute to cognition and motor impairment in MS, two major disabling problems for patients. We will advance the possibilities of MRI to capture cortical involvement in Danish MS patients with the goal to improve individual stratification, monitoring of disease progression and capturing of the individual response to therapy.

Selected Publications

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Madsen MAJ, Wiggermann V, Marques MFM, Lundell H, Cerri S, Puonti O, Blinkenberg M, Christensen JR, Sellebjerg F & Siebner HR, Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: a 7 T MRI study,

[map[#text:Brain -lang:en] map[#text:Brain -lang:en] map[#text:Brain : a journal of neurology -lang:en]] 

  vol 145, Issue 10, p. 3522-3535, (2022). DOI:10.1093/brain/awac203

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Madsen MAJ, Wiggermann V, Bramow S, Christensen JR, Sellebjerg F & Siebner HR, Imaging cortical multiple sclerosis lesions with ultra-high field MRI

[map[#text:NeuroImage: Clinical -lang:en] map[#text:NeuroImage. Clinical -lang:en]] 

  vol 32, p. 1-14, (2021). DOI:10.1016/j.nicl.2021.102847

Madsen MAJ, Povazan M, Wiggermann V, Lundell H, Blinkenberg M, Romme Christensen J, Sellebjerg F, Siebner HR. 2024. Association of cortical lesions with regional glutamate, GABA, N-Acetylaspartate, and Myoinositol levels in patients with multiple sclerosis. Neurology. 103(1): e209543. https://doi.org/10.1212/WNL.0000000000209543

Madsen MAJ, Wiggermann V, Marques MFM, Lundell H, Cerri S, Puonti O, Blinkenberg M, Romme Christensen J, Sellebjerg F, Siebner HR. Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: A 7 T MRI study. Brain, 145(10), 2022, DOI: 10.1093/awac203

Madsen MAJ, Wiggermann V, Bramow S, Romme Christensen J, Sellebjerg F, Siebner HR. Imaging cortical multiple sclerosis lesions with ultra-high field MRI. NeuroImage: Clinical, 32, 2021, DOI:10.1016/j.nicl.2021.102847