James Rowe

Visiting Professor

Research Interests

I work for the better understanding, diagnosis and treatment of degenerative brain diseases, including dementia and parkinsonian disorders. With my UK based group, we bring together computational models of brain and behaviour, physiology (MEG), structural and functional brain imaging (3T and 7T), and biomarkers of pathology (PET/blood), genetics and experimental treatments. I am here on sabbatical, having enjoyed working at DRCMR before, in 2004 and 2019.

Contact Details

James Rowe

Visiting Professor

jamesr@drcmr.dk

Affiliations

University of Copenhagen and University of Cambridge

Employments

2020 – Present

Associate Director, Dementia Platform UK

2020 – Present

Chief Scientific Advisor, Alzheimer Research UK

2015 – Present

Professor of Cognitive Neurology, Cambridge University

2015 – Present

Affiliated Professor of Clincial Neuroscience, Copenhagen

2013 – Present

Cambridge University Hospitals NHS Trust Dementia Lead

2010 – 2015

Reader in Cognitive Neurology, University of Cambridge

2009 – 2021

Wellcome Trust Senior Research Fellow in Clinical Science

2009 – Present

Program Leader, MRC Cognition and Brain Sciences Unit

2005 – Present

Consultant Neurologist, Addenbrooke's Hospital, Cambridge

2005 – 2009

Wellcome Trust Clinical Research Fellow

2004 – 2005

DRCMR Postdoc and Reservelæge, Rigshospitalet

Education

2012

FRCP, London

2005

CCT Neurology

2001

PhD in Neuroscience, UCL

1997

MRCP

1994

BM BCh in Medicine, University of Oxford

1991

BSc in Experimental Psychology, University of Cambridge

Publications

Kaalund SS, Passamonti L, Allinson KSJ, Murley AG, Robbins TW, Spillantini MG and Rowe JB (2020), 'Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity', Acta neuropathologica communications, 8(1):1-11, doi:10.1186/s40478-020-0886-0

Correia MM, Rittman T, Barnes CL, Coyle-Gilchrist IT, Ghosh B, Hughes LE and Rowe JB (2020), 'Towards accurate and unbiased imaging-based differentiation of Parkinson's disease, progressive supranuclear palsy and corticobasal syndrome', Brain communications, 2(1):1-18, doi:10.1093/braincomms/fcaa051

Düzel E, Acosta-Cabronero J, Berron D, Biessels GJ, Björkman-Burtscher I, Bottlaender M, Bowtell R, Buchem MV, Cardenas-Blanco A, Boumezbeur F, Chan D, Clare S, Costagli M, De Rochefort L, Fillmer A, Gowland P, Hansson O, Hendrikse J, Kraff O, Ladd ME, Ronen I, Petersen E, Rowe JB, Siebner H, Stoecker T, Straub S, Tosetti M, Uludag K, Vignaud A, Zwanenburg J and Speck O (2019), 'European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11:538-549, doi:10.1016/j.dadm.2019.04.010

Van Eimeren T, Antonini A, Berg D, Bohnen N, Ceravolo R, Drzezga A, Höglinger GU, Higuchi M, Lehericy S, Lewis S, Monchi O, Nestor P, Ondrus M, Pavese N, Peralta MC, Piccini P, Pineda-Pardo JÁ, Rektorová I, Rodríguez-Oroz M, Rominger A, Seppi K, Stoessl AJ, Tessitore A, Thobois S, Kaasinen V, Wenning G, Siebner HR, Strafella AP and Rowe JB (2019), 'Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11:301-309, doi:10.1016/j.dadm.2019.01.011

Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maaß A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Düzel E and Hämmerer D (2019), 'Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases', Brain, 142(9):2558-2571, doi:10.1093/brain/awz193

Dagher A, Lehéricy S, Rowe JB and Siebner HR (2019), unknown publication 18fc4598-3316-4d22-9fa0-6e026aac940e, doi:10.1016/j.neuroimage.2019.02.040

Hornboll B, Macoveanu J, Nejad A, Rowe J, Elliott R, Knudsen GM, Siebner HR and Paulson OB (2018), 'Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex', Scientific Reports, 8(1):17889, doi:10.1038/s41598-018-36350-y

Lehéricy S, Vaillancourt DE, Seppi K, Monchi O, Rektorova I, Antonini A, McKeown MJ, Masellis M, Berg D, Rowe JB, Lewis SJG, Williams-Gray CH, Tessitore A and Siebner HR (2017), 'The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward', Movement Disorders, 32(4):510-525, doi:10.1002/mds.26968

Herz DM, Haagensen BN, Christensen MS, Madsen KH, Rowe JB, Løkkegaard A and Siebner HR (2015), 'Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans', Brain, 138(Pt 6):1658-1666, doi:10.1093/brain/awv096

Herz DM, Haagensen BN, Christensen MS, Madsen KH, Rowe JB, Løkkegaard A and Siebner HR (2014), 'The acute brain response to levodopa heralds dyskinesias in Parkinson disease', Annals of Neurology, 75(6):829-836, doi:10.1002/ana.24138

Siebner HR, Strafella AP and Rowe JB (2014), 'The white elephant revived: A new marriage between PET and MRI: Comment to Cumming: "PET Neuroimaging: The White Elephant Packs His Trunk?"', NeuroImage, 84:1104-1106, doi:10.1016/j.neuroimage.2013.09.052

Wolpe N, Haggard P, Siebner HR and Rowe JB (2013), 'Cue integration and the perception of action in intentional binding', Experimental Brain Research, 229(3):467-474, doi:10.1007/s00221-013-3419-2

Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM and Siebner HR (2013), 'Playing it safe but losing anyway-Serotonergic signaling of negative outcomes in dorsomedial prefrontal cortex in the context of risk-aversion', European Neuropsychopharmacology, 23(8):919-930, doi:10.1016/j.euroneuro.2012.09.006

Rowe JB and Siebner HR (2012), 'The motor system and its disorders', NeuroImage, 61(2):464-477, doi:10.1016/j.neuroimage.2011.12.042

Christensen MS, Kristiansen L, Rowe JB and Nielsen JB (2008), 'Action-blindsight in healthy subjects after transcranial magnetic stimulation.', National Academy of Sciences. Proceedings, 105(4):1353-1357, doi:10.1073/pnas.0705858105

Korsholm K, Madsen K, Frederiksen JL, Rowe JB and Lund TE (2008), 'Cortical neuroplasticity in patients recovering from acute optic neuritis', NeuroImage, 42(2):836-844, doi:10.1016/j.neuroimage.2008.05.031

Christensen MS, Ramsøy TZ, Lund TE, Madsen K and Rowe JB (2006), 'An fMRI study of the neural correlates of graded visual perception', NeuroImage, 31(4):1711-1725, doi:10.1016/j.neuroimage.2006.02.023

Lund TE, Nørgaard MD, Rostrup E, Rowe JB and Paulson OB (2005), 'Motion or activity: their role in intra- and inter-subject variation in fMRI.', NeuroImage, 26(3):960-964, doi:10.1016/j.neuroimage.2005.02.021

Rowe JB, Stephan KE, Friston K, Frackowiak RS and Passingham RE (2005), 'The prefrontal cortex shows context-specific changes in effective connectivity to motor or visual cortex during the selection of action or colour.', Cerebral Cortex, 15(1):85-95


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