Melissa Larsen

Research Interests

I am interested in the brain mechanisms and the connectivity underpinnings of psychotic symptoms and how these develop in the brain. In particular, I am interested in how predictive processes and oscillatory activity are disturbed in psychiatric disorders and further how this relates to brain structure. I am leading the Developmental Psychiatry group where we use a multimodal approach to elucidate the complex relationships between brain, body, cognition, and mental health and how these relationships are modulated by environmental and biological factors. We have a developmental focus since most mental disorders are rooted in abnormal neurodevelopment.

Contact Details

Melissa Larsen

Senior Researcher

melissal@drcmr.dk

Research Areas

Imaging of Disease & Mechanisms

Research Groups

Developmental Psychiatry (Leader)

Employments

2019 – Present	Postdoc, DRCMR
2017 – 2019	Postdoc, Queensland Brain Institute, University of Queensland, Australia
2017 – 2017	Postdoc, DRCMR
2012 – 2017	PhD Student, DTU Compute and DRCMR
2012 – 2012	Research Assistant, DRCMR

Education

2017	PhD in Engineering, Technical University of Denmark, DRCMR, Sankt Hans
2012	MSc in Biomedical Engineering, Technical University of Denmark
2009	BSc in Biomedical Engineering, Technical University of Denmark

Publications

Ioakeimidis V, Kaminski A, Ji A, Baaré WFC, Larsen KM, Hemager N, Gregersen M, Dietz M, Rohd S, Krantz M, Greve AN, Veddum L, Lund TE, Mors O, Thorup AAE, Østergaard L, Nordentoft M, Siebner HR, Madsen KS (2026), unknown publication 86e3c5be-8bbc-4dcc-b3c2-1554f019f4cd

Goodwin I, Larsen KM, Sangchooli A, Smith RE, Banaschewski T, Barker GJ, Bokde AL, Brühl R, Desrivières S, Garavan H, Gowland P, Grigis A, Heinz A, Lemaitre H, Martinot J, Martinot MP, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Hester R, Garrido MI (2025), 'Psychotic-Like Experiences and White Matter Microstructure', Human Brain Mapping, 46(17)

Bühler J, Larsen KM, Pagsberg AK, Siebner HR (2025), unknown publication d20219db-7a35-41fd-b0ae-1e6d64b7fa22

Bühler J, Larsen KM, Pagsberg AK, Siebner HR (2025), unknown publication e0282b00-861d-4210-8f5e-c480020fa786

Ioakeimidis V, Hansen MM, Baaré WFC, Hernandez-Torres E, Larsen KM, Thorup AAE, Østergaard L, Nordentoft M, Siebner HR, Madsen KS (2025), unknown publication 7a44156c-4e3a-4107-ace7-491be8392751

Madsen KS, Baaré WFC, Hernandez-Torres E, Larsen KM, Kaminski A, Johnsen LK, Hemager N, Gregersen M, Brandt JM, Krantz MF, Weye N, Søndergaard A, Greve AN, Knudsen CB, Andreassen AK, Veddum L, Lund TE, Mors O, Elgaard Thorup AA, Østergaard L, Nordentoft M, Siebner HR (2025), 'Sex-specific cortical brain differences in children at familial high risk for schizophrenia or bipolar disorder', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Kaminski A, Baaré WFC, Hernandez-Torres E, Larsen KM, Korsgaard L, Hemager N, Gregersen M, Brandt JM, Krantz MF, Weye N, Søndergaard A, Greve AN, Bruun Knudsen C, Andreasen AK, Veddum L, Ellegaard Lund T, Mors O, Thorup AAE, Østergaard L, Nordentoft M, Siebner HR, Madsen KS (2025), unknown publication 772c0000-5175-481a-80e8-6f210ce7ee87

Bühler J, Larsen KM, Pagsberg AK, Siebner HR (2025), unknown publication b7719086-fee2-4bb8-b6d6-c2f482b6ea7d

Larsen KM, Thapaliya K, Barth M, Lin CS, Siebner HR, Garrido MI (2025), 'Phase Locking of 40 Hz Auditory Steady State Responses Is Modulated by Sensory Predictability and Linked to Cerebellar Myelination', Human Brain Mapping, 46(5)

Larsen KM, Díaz-I-Calvete J, Ver Loren van Themaat AH, Elgaard Thorup AA, Plessen KJ, Nordentoft M, Siebner HR (2025), 'Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls', NeuroImage: Clinical, 48

Plachti A, Baaré WFC, Hernandez-Torres E, Larsen KM, Thorup AAE, Nordentoft M, Siebner HR, Madsen KS (2024), unknown publication bc7aaf25-8573-46e3-b990-6a3a4b76a6cb

Johnsen LK, Larsen KM, Fuglsang SA, Ver Loren van Themaat AH, Baaré WFC, Madsen KS, Madsen KH, Hemager N, Andreassen AK, Veddum L, Greve AN, Nejad AB, Burton BK, Gregersen M, Eichele H, Lund TE, Bliksted V, Thorup AAE, Mors O, Plessen KJ, Nordentoft M, Siebner HR (2023), 'Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder', Schizophrenia Bulletin, 50(3):567-578

Jefsen OH, Shtyrov Y, Larsen KM, Dietz MJ (2022), 'The 40-Hz auditory steady-state response in bipolar disorder', Clinical Neurophysiology, 141:53-61

Larsen KM (2022), unknown publication 42228427-c464-4aa8-b6f0-d522cbdfd9e2

Dzafic I, Larsen KM, Darke H, Pertile H, Carter O, Sundram S, Garrido MI (2021), 'Stronger Top-Down and Weaker Bottom-Up Frontotemporal Connections During Sensory Learning Are Associated With Severity of Psychotic Phenomena', Schizophrenia Bulletin, 47(4):1039-1047

Taylor JA, Larsen KM, Garrido MI (2020), 'Multi-dimensional predictions of psychotic symptoms via machine learning', Human Brain Mapping, 41(18):5151-5163

Larsen KM, Dzafic I, Darke H, Pertile H, Carter O, Sundram S, Garrido MI (2020), 'Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences', Schizophrenia Research, 222:185-194

Johnsen LK, Ver Loren van Themaat AH, Larsen KM, Burton BK, Baaré WFC, Madsen KS, Nordentoft M, Siebner HR, Plessen KJ (2020), 'Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review', Frontiers in Psychiatry, 11:1-16

Larsen KM, Dzafic I, Siebner HR, Garrido MI (2018), unknown publication 7f745d36-0a80-441b-89ff-b6f44e4386f8

Pellegrino G, Tomasevic L, Herz DM, Larsen KM, Siebner HR (2018), 'Theta Activity in the Left Dorsal Premotor Cortex During Action Re-Evaluation and Motor Reprogramming', Frontiers in Human Neuroscience, 12(364)

Larsen KM, Pellegrino G, Birknow MR, Kjær TN, Baaré WFC, Didriksen M, Olsen L, Werge T, Mørup M, Siebner HR (2018), '22q11.2 Deletion Syndrome Is Associated With Impaired Auditory Steady-State Gamma Response', Schizophrenia Bulletin, 44(2):388-397

Larsen KM, Mørup M, Siebner HR, Baaré WFC, Werge TM (2017), unknown publication 75f7609c-dcf0-48c3-b815-18854273baf2

Larsen KM, Pellegrino G, Rosgaard Birknow M, Baaré WFC, Didriksen M, Olsen L, Werge TM, Siebner HR, Mørup M (2016), unknown publication ca3c1ace-f847-4f82-bb95-d61fc65d4a15

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