Henrik Lundell

Senior Researcher

Research Interests

My main interest is mainly to find biomarkers for structural and microstructural tissue changes in healthy and disease. My work spans from method development on pre-clinical scanners to translation to in vivo applications in humans.

Employments

2018 – Present

Senior Researcher, DRCMR

2011 – 2018

Postdoc, DRCMR

2010 – 2011

Research Assistent, DRCMR

2007 – 2010

PhD Student, University of Copenhagen, Denmark

2007 – 2007

Research Assistent, University of Copenhagen, Denmark

2005 – 2005

Research Inter, BMW Forschung und Technik GmbH, Munich

2000 – 2000

Research Assistent, Mechanics Department, Royal Institute of Technology (KTH), Stockholm

Publications

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Jokivuolle M, Lundell H, Madsen KH, Poulsen FR, Petersen JK, Grønhøj MH, Harbo FSG, Wirenfeldt M, Dahlrot RH, Ewald JD, Bisgaard ALH & Mahmood F, Mapping cell density and hypoxia in glioblastoma using time-dependent diffusion MRI: improved cell density assessment compared to conventional diffusion metrics,

[map[#text:Physics in Medicine and Biology -lang:en] map[#text:Phys Med Biol -lang:en]] 

  vol 70, Issue 14, 145029, (2025). DOI:10.1088/1361-6560/adece1

Jokivuolle M, Mahmood F, Madsen KH, Harbo FSG, Johnsen L & Lundell H, Assessing tumor microstructure with time-dependent diffusion imaging: Considerations and feasibility on clinical MRI and MRI-Linac,

map[#text:Medical Physics -lang:en] 

Medical Physics  vol 52, Issue 1, p. 346-361, (2024). DOI:10.1002/mp.17453

Lasič S, Just N, Nilsson M, Szczepankiewicz F, Budde M & Lundell H, Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain

map[#text:Imaging Neuroscience -lang:en] 

Imaging Neuroscience  vol 3, IMAG.a.35, (2025). DOI:10.1162/IMAG.a.35

Winther S, Lundell H, Rafael-Patiño J, Andersson M, Thiran J & Dyrby TB, Susceptibility-induced internal gradients reveal axon morphology and cause anisotropic effects in the diffusion-weighted MRI signal

[map[#text:Scientific Reports -lang:en] map[#text:Scientific Reports -lang:en]] 

  vol 14, Issue 1, p. 29636-29636, (2024). DOI:10.1038/s41598-024-79043-5

Lasič S, Chakwizira A, Lundell H, Westin C & Nilsson M, Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?,

[map[#text:NMR in Biomedicine -lang:en] map[#text:N M R in Biomedicine -lang:en] map[#text:N M R in Biomedicine (Online) -lang:en]] 

  vol 37, Issue 11, p. 1-22, (2024). DOI:10.1002/nbm.5208

Ligneul C, Najac C, Döring A, Beaulieu C, Branzoli F, Clarke WT, Cudalbu C, Genovese G, Jbabdi S, Jelescu I, Karampinos D, Kreis R, Lundell H, Marjańska M, Möller HE, Mosso J, Mougel E, Posse S, Ruschke S, Simsek K, Szczepankiewicz F, Tal A, Tax C, Oeltzschner G, Palombo M, Ronen I & Valette J, Diffusion-weighted MR spectroscopy: Consensus, recommendations, and resources from acquisition to modeling,

[map[#text:Magnetic Resonance in Medicine -lang:en] map[#text:Journal of Magnetic Resonans in Medicine -lang:en] map[#text:Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine -lang:en] map[#text:Magnetic Resonance medicine -lang:en]] 

  vol 91, Issue 3, p. 860-885, (2024). DOI:10.1002/mrm.29877

Farkhani S, Demnitz N, Boraxbekk C, Lundell H, Siebner HR, Petersen ET & Madsen KH, End-to-end volumetric segmentation of white matter hyperintensities using deep learning

[map[#text:Computer Methods and Programs in Biomedicine -lang:en] map[#text:Computer Programs in Biomedicine -lang:en]] 

  vol 245, p. 1-11, (2024). DOI:10.1016/j.cmpb.2024.108008

Lundell H & Steele CJ, Cerebellar imaging with diffusion magnetic resonance imaging: approaches, challenges, and potential

map[#text:Current Opinion in Behavioral Sciences -lang:en] 

Current Opinion in Behavioral Sciences  vol 56, p. 1-7, (2024). DOI:10.1016/j.cobeha.2024.101353

Cerri S, Greve DN, Hoopes A, Lundell H, Siebner HR, Mühlau M & Van Leemput K, An open-source tool for longitudinal whole-brain and white matter lesion segmentation

[map[#text:NeuroImage: Clinical -lang:en] map[#text:NeuroImage. Clinical -lang:en]] 

  vol 38, p. 1-19, (2023). DOI:10.1016/j.nicl.2023.103354

Talbot J, Højsgaard Chow H, Mahler M, Buhelt S, Holm Hansen R, Lundell H, Vinther-Jensen T, Hellem MNN, Nielsen JE, Siebner HR, von Essen MR & Sellebjerg F, Relationship between cerebrospinal fluid biomarkers of inflammation and tissue damage in primary progressive multiple sclerosis

map[#text:Multiple Sclerosis and Related Disorders -lang:en] 

Multiple Sclerosis and Related Disorders  vol 68, p. 104209-104209, (2022). DOI:10.1016/j.msard.2022.104209

Madsen MAJ, Wiggermann V, Marques MFM, Lundell H, Cerri S, Puonti O, Blinkenberg M, Christensen JR, Sellebjerg F & Siebner HR, Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: a 7 T MRI study,

[map[#text:Brain -lang:en] map[#text:Brain -lang:en] map[#text:Brain : a journal of neurology -lang:en]] 

  vol 145, Issue 10, p. 3522-3535, (2022). DOI:10.1093/brain/awac203

Lasič S, Yuldasheva N, Szczepankiewicz F, Nilsson M, Budde M, Dall’Armellina E, Schneider JE, Teh I & Lundell H, Stay on the Beat With Tensor-Valued Encoding: Time-Dependent Diffusion and Cell Size Estimation in ex vivo Heart,

map[#text:Frontiers in Physics -lang:en] 

Frontiers in Physics  vol 10, p. 1-19, (2022). DOI:10.3389/fphy.2022.812115

Andersson M, Pizzolato M, Kjer HM, Skodborg KF, Lundell H & Dyrby TB, Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures?

map[#text:NeuroImage -lang:en] 

NeuroImage  vol 248, p. 1-18, (2021). DOI:10.1016/j.neuroimage.2021.118718

Rahbek S, Madsen KH, Lundell H, Mahmood F & Hanson LG, Data-driven separation of MRI signal components for tissue characterization

[map[#text:Journal of Magnetic Resonance -lang:en] map[#text:J Magn Reson B -lang:en] map[#text:Journal of magnetic resonance (San Diego, Calif. : 1997) -lang:en] map[#text:Journal of Magnetic Resonance - Series A -lang:en]] 

  vol 333, p. 1-11, (2021). DOI:10.1016/j.jmr.2021.107103

Chow HH, Talbot J, Marstrand L, Lundell H, Roman Siebner H, Bach Søndergaard H & Sellebjerg F, Smoking, cardiovascular risk factors and LRP2 gene variation: Associations with disease severity, cognitive function and brain structure in primary progressive multiple sclerosis,

map[#text:Multiple Sclerosis and Related Disorders -lang:en] 

Multiple Sclerosis and Related Disorders  vol 56, p. 1-7, (2021). DOI:10.1016/j.msard.2021.103296

Højsgaard Chow H, Talbot J, Lundell H, Gøbel Madsen C, Marstrand L, Lange T, Mahler MR, Buhelt S, Holm Hansen R, Blinkenberg M, Romme Christensen J, Soelberg Sørensen P, Rode von Essen M, Siebner HR & Sellebjerg F, Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis: A Randomized, Controlled Trial,

[map[#text:Neurology: Neuroimmunology and NeuroInflammation -lang:en] map[#text:Neurology: Neuroimmunology and NeuroInflammation -lang:en] map[#text:Neurology® neuroimmunology & neuroinflammation -lang:en] map[#text:Neurol Neuroimmunol Neuroinflamm -lang:en]] 

  vol 8, Issue 5, p. 1-11, (2021). DOI:10.1212/NXI.0000000000001037

Lundell H, Najac C, Bulk M, Kan HE, Webb AG & Ronen I, Compartmental diffusion and microstructural properties of human brain gray and white matter studied with double diffusion encoding magnetic resonance spectroscopy of metabolites and water

map[#text:NeuroImage -lang:en] 

NeuroImage  vol 234, p. 1-14, (2021). DOI:10.1016/j.neuroimage.2021.117981

Lundell H, Ingo C, Dyrby TB & Ronen I, Cytosolic diffusivity and microscopic anisotropy of N-acetyl aspartate in human white matter with diffusion-weighted MRS at 7 T

[map[#text:NMR in Biomedicine -lang:en] map[#text:N M R in Biomedicine -lang:en] map[#text:N M R in Biomedicine (Online) -lang:en]] 

  vol 34, Issue 5, p. 1-14, (2021). DOI:10.1002/nbm.4304

Benavides FD, Jin Jo H, Lundell H, Edgerton VR, Gerasimenko Y & Perez MA, Cortical and Subcortical Effects of Transcutaneous Spinal Cord Stimulation in Humans with Tetraplegia

[map[#text:Neuroscience Journal -lang:en] map[#text:Journal of Neuroscience -lang:en] map[#text:The European journal of neuroscience -lang:en] map[#text:The Journal of Neuroscience : the official journal of the Society for Neuroscience -lang:en] map[#text:J Neurosci -lang:en]] 

  vol 40, Issue 13, p. 2633-2643, (2020). DOI:10.1523/JNEUROSCI.2374-19.2020

Postans M, Parker GD, Lundell H, Ptito M, Hamandi K, Gray WP, Aggleton JP, Dyrby TB, Jones DK & Winter M, Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory

[map[#text:Cerebral Cortex -lang:en] map[#text:Cerebral Cortex -lang:en]] 

  vol 30, Issue 3, p. 1001-1015, (2019). DOI:10.1093/cercor/bhz143

Ambrosen KS, Eskildsen SF, Hinne M, Krug K, Lundell H, Schmidt MN, van Gerven MAJ, Mørup M & Dyrby TB, Validation of structural brain connectivity networks: The impact of scanning parameters,

map[#text:NeuroImage -lang:en] 

NeuroImage  vol 204, p. 1-13, (2019). DOI:10.1016/j.neuroimage.2019.116207

Andersen KW, Lasič S, Lundell H, Nilsson M, Topgaard D, Sellebjerg F, Szczepankiewicz F, Siebner HR, Blinkenberg M & Dyrby TB, Disentangling white-matter damage from physiological fibre orientation dispersion in multiple sclerosis

map[#text:Brain communications -lang:en] 

Brain communications  vol 2, Issue 2, p. 1-14, (2020). DOI:10.1093/braincomms/fcaa077

Sangari S, Lundell H, Kirshblum S & Perez MA, Residual Descending Motor Pathways Influence Spasticity after Spinal Cord Injury

map[#text:Annals of Neurology -lang:en] 

Annals of Neurology  vol 86, Issue 1, p. 28-41, (2019). DOI:10.1002/ana.25505

Lundell H, Nilsson M, Dyrby TB, Parker GJM, Cristinacce PLH, Zhou F, Topgaard D & Lasič S, Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail

[map[#text:Scientific Reports -lang:en] map[#text:Scientific Reports -lang:en]] 

  vol 9, Issue 1, p. 1-12, (2019). DOI:10.1038/s41598-019-45235-7

Lasič S, Lundell H, Topgaard D & Dyrby TB, Effects of imaging gradients in sequences with varying longitudinal storage time-Case of diffusion exchange imaging

[map[#text:Magnetic Resonance in Medicine -lang:en] map[#text:Journal of Magnetic Resonans in Medicine -lang:en] map[#text:Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine -lang:en] map[#text:Magnetic Resonance medicine -lang:en]] 

  vol 79, p. 2228-2235, (2018). DOI:10.1002/mrm.26856

Nielsen JS, Dyrby TB & Lundell H, Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue

[map[#text:Scientific Reports -lang:en] map[#text:Scientific Reports -lang:en]] 

  vol 8, Issue 2930, (2018). DOI:10.1038/s41598-018-19475-y

Lundell H, Svolgaard O, Dogonowski A, Romme Christensen J, Selleberg F, Soelberg Sørensen P, Blinkenberg M, Siebner HR & Garde E, Spinal cord atrophy in anterior-posterior direction reflects impairment in multiple sclerosis

map[#text:Acta Neurologica Scandinavica -lang:en] 

Acta Neurologica Scandinavica  vol 136, Issue 4, p. 330-337, (2017). DOI:10.1111/ane.12729

Reislev NH, Dyrby TB, Siebner HR, Lundell H, Ptito M & Kupers R, Thalamocortical Connectivity and Microstructural Changes in Congenital and Late Blindness

[map[#text:Journal of Neural Transplantation and Plasticity -lang:en] map[#text:Neural Plasticity -lang:en] map[#text:Journal of Neural Transplantation -lang:en]] 

  vol 2017, p. 9807512-9807512, (2017). DOI:10.1155/2017/9807512

Shemesh N, Jespersen SN, Alexander DC, Cohen Y, Drobnjak I, Dyrby TB, Finsterbusch J, Koch M, Kuder T, Laun F, Lawrenz M, Lundell H, Mitra PP, Nilsson M, Özarslan E, Topgaard D & Westin C, Conventions and nomenclature for double diffusion encoding NMR and MRI

[map[#text:Magnetic Resonance in Medicine -lang:en] map[#text:Journal of Magnetic Resonans in Medicine -lang:en] map[#text:Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine -lang:en] map[#text:Magnetic Resonance medicine -lang:en]] 

  vol 75, Issue 1, p. 82-87, (2016). DOI:10.1002/mrm.25901

Lundell H, Sønderby CK & Dyrby TB, Diffusion weighted imaging with circularly polarized oscillating gradients

[map[#text:Magnetic Resonance in Medicine -lang:en] map[#text:Journal of Magnetic Resonans in Medicine -lang:en] map[#text:Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine -lang:en] map[#text:Magnetic Resonance medicine -lang:en]] 

  vol 73, Issue 3, p. 1171-1176, (2015). DOI:10.1002/mrm.25211

Barthélemy D, Willerslev-Olsen M, Lundell H, Biering-Sørensen F & Nielsen JB, Assessment of transmission in specific descending pathways in relation to gait and balance following spinal cord injury

map[#text:Progress in Brain Research -lang:en] 

Progress in Brain Research  vol 218, p. 79-101, (2015). DOI:10.1016/bs.pbr.2014.12.012

Dyrby TB, Lundell H, Burke MW, Reislev NL, Paulson OB, Ptito M & Siebner HR, Interpolation of diffusion weighted imaging datasets

map[#text:NeuroImage -lang:en] 

NeuroImage  vol 103C, p. 202-213, (2014). DOI:10.1016/j.neuroimage.2014.09.005

Sønderby CK, Lundell HM, Søgaard LV & Dyrby TB, Apparent exchange rate imaging in anisotropic systems

[map[#text:Magnetic Resonance in Medicine -lang:en] map[#text:Journal of Magnetic Resonans in Medicine -lang:en] map[#text:Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine -lang:en] map[#text:Magnetic Resonance medicine -lang:en]] 

  vol 72, Issue 3, p. 756-762, (2014). DOI:10.1002/mrm.24957

Lundell H, Alexander DC & Dyrby TB, High angular resolution diffusion imaging with stimulated echoes: compensation and correction in experiment design and analysis,

[map[#text:NMR in Biomedicine -lang:en] map[#text:N M R in Biomedicine -lang:en] map[#text:N M R in Biomedicine (Online) -lang:en]] 

  vol 27, Issue 8, p. 918-925, (2014). DOI:10.1002/nbm.3137

Jespersen SN, Lundell H, Sønderby CK & Dyrby TB, Orientationally invariant metrics of apparent compartment eccentricity from double pulsed field gradient diffusion experiments

[map[#text:NMR in Biomedicine -lang:en] map[#text:N M R in Biomedicine -lang:en] map[#text:N M R in Biomedicine (Online) -lang:en]] 

  vol 26, Issue 12, p. 1647-1662, (2013). DOI:10.1002/nbm.2999

Barthélemy D, Knudsen H, Willerslev-Olsen M, Lundell H, Nielsen JB & Biering-Sørensen F, Functional implications of corticospinal tract impairment on gait after spinal cord injury

[map[#text:Spinal Cord -lang:en] map[#text:Spinal cord : the official journal of the International Medical Society of Paraplegia -lang:en] map[#text:Paraplegia -lang:en]] 

  vol 51, Issue 11, p. 852-856, (2013). DOI:10.1038/sc.2013.84

Assaf Y, Alexander DC, Jones DK, Bizzi A, Behrens T, Clark CA, Cohen Y, Dyrby TB, Huppi PS, Knoesche TR, Lebihan D, Parker GJM, Poupon C, Anaby D, Anwander A, Bar L, Barazany D, Blumenfeld-Katzir T, De-Santis S, Duclap D, Figini M, Fischi E, Guevara P, Hubbard P, Hofstetter S, Jbabdi S, Kunz N, Lazeyras F, Lebois A, Liptrot MG, Lundell H, Mangin J, Dominguez DM, Morozov D, Schreiber J, Seunarine K, Nava S, Poupon C, Riffert T, Sasson E, Schmitt B, Shemesh N, Sotiropoulos SN, Tavor I, Zhang HG & Zhou F, The CONNECT project: Combining macro- and micro-structure,

map[#text:NeuroImage -lang:en] 

NeuroImage  vol 80, p. 273-282, (2013). DOI:10.1016/j.neuroimage.2013.05.055

Lundell H, Barthelemy D, Biering-Sørensen F, Cohen-Adad J, Nielsen JB & Dyrby TB, Fast diffusion tensor imaging and tractography of the whole cervical spinal cord using point spread function corrected echo planar imaging

[map[#text:Magnetic Resonance in Medicine -lang:en] map[#text:Journal of Magnetic Resonans in Medicine -lang:en] map[#text:Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine -lang:en] map[#text:Magnetic Resonance medicine -lang:en]] 

  vol 69, Issue 1, p. 144-149, (2013). DOI:10.1002/mrm.24235

Lundell H, Nielsen JB, Ptito M & Dyrby TB, Distribution of collateral fibers in the monkey cervical spinal cord detected with diffusion-weighted magnetic resonance imaging

map[#text:NeuroImage -lang:en] 

NeuroImage  vol 56, Issue 3, p. 923-929, (2011). DOI:10.1016/j.neuroimage.2011.02.043

Lundell H, Barthelemy D, Skimminge A, Dyrby TB, Biering-Sørensen F & Nielsen JB, Independent spinal cord atrophy measures correlate to motor and sensory deficits in individuals with spinal cord injury

[map[#text:Spinal Cord -lang:en] map[#text:Spinal cord : the official journal of the International Medical Society of Paraplegia -lang:en] map[#text:Paraplegia -lang:en]] 

  vol 49, Issue 1, p. 70-75, (2011). DOI:10.1038/sc.2010.87


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