Lars G. Hanson

Senior Researcher, Associate Professor

Research Interests

Research topics: Medical Magnetic Resonance Imaging (MRI) techniques and applications. Sequence development, spectroscopy, functional og dynamic measurements, visualization and MR physics.Overview: The research focus is MRI methodology and technology in a broad sense. This includes imaging and spectroscopy methodology, mostly of general nature or for brain. The developed techniques were used in studies of multiple sclerosis, depression, MLD, and muscle energetics, for example. Recent research includes hyperpolarized imaging, fast spectroscopic imaging, motion correction, and encoding of non-MR signals in MRI, e.g. for artifact correction. Interests also include MR fundamentals, and development of widely used educational material and software made freely available via the DRCMR homepage.Affiliations: Senior Scientist and group leader at the DRCMR (http://www.drcmr.dk/acquisition). Also Associate Professor at the DTU Center for Magnetic Resonance (http://www.cmr.healthtech.dtu.dk/) and active in the Center for Hyperpolarization in Magnetic Resonance (http://www.hypermag.dtu.dk/).Teaching: Course in MRI understanding at DRCMR (http://www.drcmr.dk/mri-course) for a broad audience, and various technical MRI courses at DTU (see list via links above).

Contact Details

Lars G. Hanson

Senior Researcher, Associate Professor

+45 6061 1362

larsh@drcmr.dk

Affiliations

Technical University of Denmark

Employments

2009 – Present

Associate Professor, Technical University of Denmark

1999 – Present

Senior Researcher, DRCMR

1996 – 1999

Introductory and Ph.D Stipend, DRCMR

1995 – 1996

Promotion Stipend, Max Planck Institute for Quantum Optics, Germany

Education

1999

Ph.D., University of Copenhagen, Denmark

1995

M.Sc. Physics, University of Copenhagen, Denmark

Publications

Cunha T, Gregersen F, Hanson LG and Thielscher A (2026), 'Increased brain coverage and efficiency when measuring current-induced magnetic fields by use of simultaneous multi-slice echo-planar MRI', PLOS ONE, 21(1), doi:10.1371/journal.pone.0341731

Gregersen F, Cunha T, Thielscher A and Hanson LG (2025), 'Increasing the measurable frequency range of magnetic field oscillations with off-resonance spin-lock preparation pulses', Magnetic Resonance in Medicine, 95(3):1634-1643, doi:10.1002/mrm.70116

Garnæs MF, Olin RB, Jensen PR, Ardenkjaer-Larsen JH, Madsen KH and Hanson LG (2025), 'Optimal Variable Flip Angle Schemes for Hyperpolarized MR Kinetic Modeling Robust to RF Field Variations', NMR in Biomedicine, 38(11), doi:10.1002/nbm.70151

Zhao Y, Olin RB, Hansen ESS, Laustsen C, Hanson LG and Ardenkjær-Larsen JH (2024), '3D quantitative myocardial perfusion imaging with hyperpolarized HP001(bis-1,1-(hydroxymethyl)-[1-13C]cyclopropane-d8): Application of gradient echo and balanced SSFP sequences', Magnetic Resonance in Medicine, 93(2):814-827, doi:10.1002/mrm.30320

Zhao Y, Lerche MH, Karlsson M, Olin RB, Hansen ESS, Aastrup M, Redda M, Laustsen C, Hanson LG and Ardenkjær-Larsen JH (2024), 'Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification', Tomography (Ann Arbor, Mich.), 10(7):1113-1122, doi:10.3390/tomography10070084

Gregersen F, Eroğlu HH, Göksu C, Puonti O, Zuo Z, Thielscher A and Hanson L (2024), 'MR imaging of the magnetic fields induced by injected currents can guide improvements of individualized head volume conductor models', Imaging Neuroscience, 2:1-15, doi:10.1162/imag_a_00176

Hanson L, Eriksen TA and Henneberg K (2024), 'En ingeniøruddannelse der giver livskvalitet', Fagbladet Medicoteknik, 2:25-28

Göksu C, Gregersen F, Scheffler K, Eroğlu HH, Heule R, Siebner HR, Hanson LG and Thielscher A (2023), 'Volumetric measurements of weak current-induced magnetic fields in the human brain at high resolution', Magnetic Resonance in Medicine, 90(5):1874-1888, doi:10.1002/mrm.29780

Hosseini S, Puonti O, Treeby B, Hanson LG and Thielscher A (2023), 'A Head Template for Computational Dose Modelling for Transcranial Focused Ultrasound Stimulation', NeuroImage, 277:1-14, doi:10.1016/j.neuroimage.2023.120227

Rahbek S, Schakel T, Mahmood F, Madsen KH, Philippens MEP and Hanson LG (2022), 'Optimized flip angle schemes for the split acquisition of fast spin-echo signals (SPLICE) sequence and application to diffusion-weighted imaging', Magnetic Resonance in Medicine, 89(4):1469-1480, doi:10.1002/mrm.29545

Rahbek S, Mahmood F, Tomaszewski MR, Hanson LG and Madsen KH (2022), 'Decomposition-based framework for tumor classification and prediction of treatment response from longitudinal MRI', Physics in Medicine and Biology, 68(2), doi:10.1088/1361-6560/acaa85

Laustsen M, Andersen M, Xue R, Madsen KH and Hanson LG (2022), 'Tracking of rigid head motion during MRI using an EEG system', Magnetic Resonance in Medicine, 88(2):986-1001, doi:10.1002/mrm.29251

Rahbek S, Madsen KH, Lundell H, Mahmood F and Hanson LG (2021), 'Data-driven separation of MRI signal components for tissue characterization', Journal of Magnetic Resonance, 333:1-11, doi:10.1016/j.jmr.2021.107103

Göksu C, Scheffler K, Gregersen F, Eroğlu HH, Heule R, Siebner HR, Hanson LG and Thielscher A (2021), 'Sensitivity and resolution improvement for in vivo magnetic resonance current-density imaging of the human brain', Magnetic Resonance in Medicine, 86(6):3131-3146, doi:10.1002/mrm.28944

Eroğlu HH, Puonti O, Göksu C, Gregersen F, Siebner HR, Hanson LG and Thielscher A (2021), 'On the reconstruction of magnetic resonance current density images of the human brain: Pitfalls and perspectives', NeuroImage, 243:1-15, doi:10.1016/j.neuroimage.2021.118517

Busoni S, Bock M, Chmelik M, Colgan N, De Bondt T, Hanson LG, Israel M, Kugel H, Maieron M, Mazzoni LN, Seimenis I and Vestergaard P (2021), unknown publication 41799bc9-9aa4-4935-bb93-ac6f930c3a42, doi:10.1016/j.ejmp.2021.07.017

Gregersen F, Göksu C, Schaefers G, Xue R, Thielscher A and Hanson LG (2021), 'Safety Evaluation of a New Setup for Transcranial Electric Stimulation during Magnetic Resonance Imaging', Brain Stimulation, 14(3):488-497, doi:10.1016/j.brs.2021.02.019

Sánchez-Heredia JD, Olin RB, McLean MA, Laustsen C, Hansen AE, Hanson LG and Ardenkjær-Larsen JH (2020), 'Multi-site benchmarking of clinical 13C RF coils at 3T', Journal of Magnetic Resonance, 318:1-11, doi:10.1016/j.jmr.2020.106798

Olin RB, Sánchez-Heredia JD, Schulte RF, Bøgh N, Hansen ESS, Laustsen C, Hanson LG and Ardenkjaer-Larsen JH (2020), 'Three-dimensional accelerated acquisition for hyperpolarized 13 C MR with blipped stack-of-spirals and conjugate-gradient SENSE', Magnetic Resonance in Medicine, 84(2):519-534, doi:10.1002/mrm.28171

Pasquinelli C, Montanaro H, Lee HJ, Hanson LG, Kim H, Kuster N, Siebner HR, Neufeld E and Thielscher A (2020), 'Transducer modeling for accurate acoustic simulations of transcranial focused ultrasound stimulation', Journal of Neural Engineering, 17(4):1-22, doi:10.1088/1741-2552/ab98dc

Ousdal OT, Argyelan M, Narr KL, Abbott C, Wade B, Vandenbulcke M, Urretavizcaya M, Tendolkar I, Takamiya A, Stek ML, Soriano-Mas C, Redlich R, Paulson OB, Oudega ML, Opel N, Nordanskog P, Kishimoto T, Kampe R, Jorgensen A, Hamilton JP, Espinoza R, Emsell L, Van Eijndhoven P, Dols A, Hanson LG, Dannlowski U, Cardoner N, Bouckaert F, Anand A, Bartsch H, Kessler U, Oedegaard KJ, Dale AM and Oltedal L (2019), 'Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed', Biological Psychiatry, 87(5):451-461, doi:10.1016/j.biopsych.2019.07.010

Groeschel S, Amedick LB, Hanson L, Wu J, Jacobsen L and Port J (2020), 'Effect of intrathecal recombinant human arylsulfatase A enzyme replacement therapy on structural brain MRI in children with metachromatic leukodystrophy', Molecular Genetics and Metabolism, 129(2):68, doi:10.1016/j.ymgme.2019.11.161

Göksu C, Hanson L, Gregersen F, Scheffler K and Thielscher A (2020), unknown publication 9b4284fb-1b17-4649-87ca-868e8b08451c

Olin RB, Sánchez-Heredia JD, McLean MA, Laustsen C, Hansen AE, Hanson L and Ardenkjaer-Larsen JH (2020), unknown publication 2e6e4ad3-f74b-47b0-9950-307e11a46ffe

Hansen RB, Sánchez-Heredia JD, Bøgh N, Hansen ESS, Laustsen C, Hanson LG and Ardenkjaer-Larsen JH (2019), 'Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI', Magnetic Resonance in Medicine, 82(6):2104-2117, doi:10.1002/mrm.27892

Pedersen JO, Hanson CG, Xue R and Hanson LG (2019), 'Inductive measurement and encoding of k-space trajectories in MR raw data', Magnetic Resonance Materials in Physics, Biology and Medicine, 32(6):655-667, doi:10.1007/s10334-019-00770-2

Pasquinelli C, Hanson LG, Siebner HR, Lee HJ and Thielscher A (2019), 'Safety of transcranial focused ultrasound stimulation: A systematic review of the state of knowledge from both human and animal studies', Brain Stimulation, 12(6):1367-1380, doi:10.1016/j.brs.2019.07.024

Göksu C, Scheffler K, Siebner HR, Thielscher A and Hanson LG (2019), 'The stray magnetic fields in Magnetic Resonance Current Density Imaging (MRCDI)', Physica Medica, 59:142-150, doi:10.1016/j.ejmp.2019.02.022

Kirkegaard-Klitbo DM, Danielsen KV, Hanson LG, Gluud LL, Siebner HR, Bendtsen F and Benfield T (2019), 'MR-skanning til diagnostik af nonalkoholisk fedtleversygdom', Ugeskrift for læger, 181(9):2-6

Magnusson PO, Boer VO, Marsman A, Paulson OB, Hanson LG and Petersen ET (2019), 'Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T', Magnetic Resonance in Medicine, 81(2):773-780, doi:10.1002/mrm.27450

Wilhjelm JE, Duun-Henriksen J and Hanson LG (2018), 'A virtual scanner for teaching fundamental magnetic resonance in biomedical engineering', Computer Applications in Engineering Education, 26(6):2197-2209, doi:10.1002/cae.22028

Oltedal L, Narr KL, Abbott C, Anand A, Argyelan M, Bartsch H, Dannlowski U, Dols A, Van Eijndhoven P, Emsell L, Erchinger VJ, Espinoza R, Hahn T, Hanson LG, Hellemann G, Jorgensen MB, Kessler U, Oudega ML, Paulson OB, Redlich R, Sienaert P, Stek ML, Tendolkar I, Vandenbulcke M, Oedegaard KJ and Dale AM (2018), 'Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy', Biological Psychiatry, 84(8):574-581, doi:10.1016/j.biopsych.2018.05.017

Pedersen JO, Hanson CG, Xue R and Hanson LG (2018), 'General purpose electronics for real-time processing and encoding of non-MR data in MR acquisitions', Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering, 48B(2):1-10, doi:10.1002/cmr.b.21385

Eldirdiri A, Posse S, Hanson LG, Hansen RB, Holst P, Schøier C, Kristensen AT, Johannesen HH, Kjaer A, Hansen AE and Ardenkjaer-Larsen JH (2018), 'Development of a Symmetric Echo-Planar Spectroscopy Imaging Framework for Hyperpolarized 13C Imaging in a Clinical PET/MR Scanner', Tomography, 4(3):110-122, doi:10.18383/j.tom.2018.00006

Göksu C, Hanson LG, Siebner HR, Ehses P, Scheffler K and Thielscher A (2018), 'Human in-vivo brain magnetic resonance current density imaging (MRCDI)', NeuroImage, 171:26-39, doi:10.1016/j.neuroimage.2017.12.075

Göksu C, Scheffler K, Ehses P, Hanson LG and Thielscher A (2018), 'Sensitivity analysis of magnetic field measurements for magnetic resonance electrical impedance tomography (MREIT)', Magnetic Resonance in Medicine, 79:748-760, doi:10.1002/mrm.26727

Møller-Bisgaard S, Ejbjerg BJ, Eshed I, Hørslev-Petersen K, Hetland ML, Jurik AG, Thomsen H, Torfing T, Stengaard-Pedersen K, Junker P, Krogh NS, Lottenburger T, Ellingsen T, Andersen LS, Skjødt H, Svendsen AJ, Tarp U, Hansen IT, Pødenphanth J, Pedersen JK, Lindegaard H, Hanson LG, Vestergaard A, Glinatsi D and Østergaard M (2017), 'Effect of a treat-to-target strategy based on methotrexate and intra-articular betamethasone with or without additional cyclosporin on MRI-assessed synovitis, osteitis, tenosynovitis, bone erosion, and joint space narrowing in early rheumatoid arthritis: results from a 2-year randomized double-blind placebo-controlled trial (CIMESTRA)', Scandinavian Journal of Rheumatology, 46(5):335-345, doi:10.1080/03009742.2016.1209550

Eldirdiri A, Kjær A, Hanson LPG and Ardenkjaer-Larsen JH (2017), 'Early detection of response to treatment in cancer by Hyperpolarized Metabolic MR'

Andersen M, Hanson LG, Madsen KH, Wezel J, Boer V, Van der Velden T, Van Osch MJP, Klomp D, Webb AG and Versluis MJ (2016), 'Measuring motion-induced B0 -fluctuations in the brain using field probes', Magnetic Resonance in Medicine, 75(5):2020-2030, doi:10.1002/mrm.25802

Herskind A, Ritterband-Rosenbaum A, Willerslev-Olsen M, Lorentzen J, Hanson L, Lichtwark G and Nielsen JB (2016), 'Muscle growth is reduced in 15-month-old children with cerebral palsy', Developmental Medicine and Child Neurology, 58(5):485-491, doi:10.1111/dmcn.12950

Jørgensen A, Magnusson P, Hanson LG, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen JD, Fink-Jensen A, Knudsen GM, Paulson OB, Bolwig TG and Jorgensen MB (2016), 'Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression', Acta Psychiatrica Scandinavica, 133:154-164, doi:10.1111/acps.12462

Nielsen AN and Hanson LPG (2016), 'Optimization of gradient trajectories for fast spectroscopic magnetic resonance imaging'

Andersen M, Hanson LPG and Madsen KH (2016), 'Towards Motion-Insensitive Magnetic Resonance Imaging Using Dynamic Field Measurements'

Hanson L (2015), unknown publication c974416c-fc77-4e0c-b243-a84a1ecfc768

Hastrup N, Khalilieh S, Dale DC, Hanson LG, Magnusson P, Tzontcheva A, Tseng J, Huyck S, Rosenberg E and Krogsgaard K (2015), 'The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects', Cytokine, 72(2):197-203, doi:10.1016/j.cyto.2015.01.002

Lund H, Krakauer M, Skimminge A, Sellebjerg F, Garde E, Siebner HR, Paulson OB, Hesse D and Hanson LG (2013), 'Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis', PLOS ONE, 8(2):56375, doi:10.1371/journal.pone.0056375

Hanson L (2012), 'MRI safety in practice: The EU directive on work in electromagnetic fields – practical and clinical aspects'

Axelsen MB, Stoltenberg M, Poggenborg RP, Kubassova O, Boesen M, Bliddal H, Hørslev-Petersen K, Hanson LG and Østergaard M (2012), 'Dynamic gadolinium-enhanced magnetic resonance imaging allows accurate assessment of the synovial inflammatory activity in rheumatoid arthritis knee joints: a comparison with synovial histology', Scandinavian Journal of Rheumatology, 41(2):89-94, doi:10.3109/03009742.2011.608375

Blinkenberg M, Mathiesen HK, Tscherning T, Jønsson A, Svarer C, Holm S, Sellebjerg F, Paulson OB, Hanson LG and Sorensen PS (2012), 'Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study', Neurological Research, 34(1):52-58, doi:10.1179/1743132811Y.0000000059

Hanson L (2012), 'Tools and methods for teaching magnetic resonance concepts and techniques', European Medical Physics News, :17-19

Hanson L (2012), 'An active learning approach to education in MRI technology for the biomedical engineering curriculum'

Hanson L (2011), unknown publication 1b6ea8c6-5a24-4892-9697-d12426fc7e45

Hanson LPG (2010), 'Introduktion til teknikken bag MR-skanning, 2. udgave'

Hanson LPG (2010), 'MR-skanning ved 7 tesla feltstyrke etableres i Danmark', Medicinsk Teknologi & Informatik, 7(4):20-22

Hanson LPG (2009), 'Introduction to Magnetic Resonance Imaging Techniques'

Hanson LPG, Skimminge A and Grüner Hanson C (2009), unknown publication 9d726610-7e54-4317-9df6-be94c06a7bc8

De Nijs R, Miranda MJ, Hansen LK and Hanson LG (2009), 'Motion correction of single-voxel spectroscopy by independent component analysis applied to spectra from nonanesthetized pediatric subjects', Magnetic Resonance in Medicine, 62(5):1147-1154, doi:10.1002/mrm.22129

Hanson LPG (2008), 'Interview om MR-sikkerhed.', Christiansborgkontakt

Hanson LPG (2008), 'Is quantum mechanics necessary for understanding Magnetic Resonance?', Concepts in Magnetic Resonance. Part A, 32A(5):329-340

Hanson LPG (2008), 'MR-skannere bliver undersøgt for kræft-risiko', videnskab.dk

Hanson LPG, I Dali C and Fogh J (2008), unknown publication aeb93301-497e-4af2-95bd-ec485721c77c

Hanson LG (2007), 'A graphical simulator for teaching basic and advanced MR imaging techniques', Radiographics, 27(6):27

Hanson LG, Lund TE and Hanson CG (2007), 'Encoding of electrophysiology and other signals in MR images.', Journal of Magnetic Resonance Imaging, 25(5):1059-1066, doi:10.1002/jmri.20906

Engholm R, Dubinskiy a, Larsen R, Hanson LPG and Christoffersen BØ (2006), unknown publication d904e15d-dbc1-440f-ab65-9a95d12832f4

Mathiesen HK, Jonsson A, Tscherning T, Hanson LG, Andresen J, Blinkenberg M, Paulson OB and Sorensen PS (2006), 'Correlation of Global N-Acetyl Aspartate With Cognitive Impairment in Multiple Sclerosis', JAMA Neurology, 63(4):533-536, doi:10.1001/archneur.63.4.533

Nielsen K, Rostrup E, Frederiksen JL, Knudsen S, Kahr Mathiesen H, Hanson LPG and Paulson OB (2006), 'Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla.', Investigative Radiology, 41(2):76-82

Hanson LPG (2006), 'MR-skanning: Billeder fra den forbudte side af bølgelængdegrænsen'

De Nijs R, Miranda Gimenez-Ricco MJ and Hanson LPG (2006), unknown publication 1447ab81-fbba-4ce8-8cbb-6ee6dcc5258e

Sørensen PS, Jønsson A, Kahr Mathiesen H, Blinkenberg M, Andresen J, Hanson LPG and Ravnborg M (2006), 'The relationship between MRI and PET changes and cognitive disturbances in MS.', Journal of the Neurological Sciences, 245(1-2):99-102

Stavngaard T, Søgaard L, Mortensen J, Hanson LPG, Scmiedeskamp J, Berthelsen AK and Dirksen A (2005), 'Hyperpolarized 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease.', European Journal Of Nuclear Medicine, 32(4):448-457

Hanson LPG (2005), unknown publication 2f6dca89-c91a-4505-800c-b58b2117f038

Mathiesen HK, Tscherning T, Sorensen PS, Larsson HBW, Rostrup E, Paulson OB and Hanson LG (2005), 'Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis', Magnetic Resonance in Medicine, 53(4):750-759, doi:10.1002/mrm.20407

Hanson LPG (2004), 'Introduktion til teknikken bag MR-skanning.'

Born AP, Law I, Lund TE, Rostrup E, Hanson LG, Wildschiødtz G, Lou HC and Paulson OB (2002), 'Cortical deactivation induced by visual stimulation in human slow-wave sleep.', NeuroImage, 17(3):1325-1335, doi:10.1006/nimg.2002.1249

Andersen IK, Szymkowiak A, Rasmussen CE, Hanson LG, Rørbech Marstrand J, Larsson HBW and Hansen LK (2002), 'Perfusion quantification using Gaussian process deconvolution.', Magnetic Resonance in Medicine, 48(2):351-361, doi:10.1002/mrm.10213

Sager T, Topp S, Torup L, Hanson LPG, Egestad B and Møller A (2001), 'Evaluation of CA1 damage using single-voxel 1H-MRS and un-biased stereology: Can non-invasive measures of N-acetyl-asparate following global ischemia be used as a reliable measure of neuronal damage?', Brain Research, 892(1):166-175

Hanson LPG, Adalsteinsson E, Pfefferbaum A and Spielman D (2000), 'Optimal voxel size for measuring global gray and white matter proton metabolite concentrations using chemical shift imaging.', Magnetic Resonance in Medicine, 44(1):10-18

Hanson LPG, Schaumburg K and Paulson OB (2000), 'Reconstruction strategy for echo planar spectroscopy and its application to partially undersampled imaging', Magnetic Resonance in Medicine, 44(3):412-417, doi:10.1002/1522-2594(200009)44:3<412::AID-MRM11>3.0.CO;2-P


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